The Mudumalai Sanctuary is an important wildlife habitat due to its strategic position as a wildlife corridor between several other protected areas making an essential part of the Nilgiri Biosphere Reserve. Its north is being crusted with Bandipur National Park and Nagarhole National Park and at its west is the Wayanad Wildlife Sanctuary along the south corner is flourished with Mukurthi National Park and Silent Valley National Park. These parks, sanctuaries and the adjoining Reserve forests cover over 3,300 sq kms of forest supporting a population of 1800–2300 elephants.
The best time to visit the park is from February to June. During this season, animals come to watering holes and lakes to quench their thirst. Spotting animals near water sources become easier. Bird population is highest during this season due to migration. The vegetation sheds its leaves and will be completely covered with flowers.